气相色谱法测定盐酸美金刚片的含量

气相色谱法测定盐酸美金刚片的含量

岳静

东北制药集团研究院

收稿日期:2013-12-24 修回日期:2014-02-18 出版日期:2014-04-25 发布日期:2014-04-25

Determination of memantine hydrochloride table conten by gas chromatography

Northeast Pharmaceutical Group Research Institute

Received:2013-12-24 Revised:2014-02-18 Online:2014-04-25 Published:2014-04-25

摘要/Abstract

摘要： 建立了测定盐酸美金刚片含量的气相色谱(GC)方法。方法采用Agilent DB-225 (30m*0.53mm,1.0μm)毛细管色谱柱,以氮气为载气,流速5mL.min-1,柱温：110℃,进样口温度：250℃,进样量：2.0μL。火焰离子化检测器(FID),检测器温度：250℃。以盐酸金刚乙胺作为内标物测定盐酸美金刚片的含量。盐酸美金刚在0.157 8mg.mL-1～0.480 6mg.mL-1范围内与峰面积呈现良好的线性关系(r=0.999 0)。所建立的方法准确、回收率较为理想,可用于盐酸美金刚片含量的测定。

Abstract: To establish a method for the determination of memantine hydrochloride. The capillary was DB-225 (30m?0.53mm ,1.0μm). The carrier gas was nitrogen gas and FID was as detector.The injector temperature was 250℃ and the detector temperature was 250℃.The assay of memantine hydrochloride by internal standard method. It appeared a good linearity in the experimental concentration(r=0.999 0).The method was accurate and the recovery rate of memantine hydrochloride is ideal, and can be used for detection of memantine hydrochloride table conten.

岳静. 气相色谱法测定盐酸美金刚片的含量[J]. .