关键词: 吗啡, 依赖, 专利分析, 专利布局

Abstract: Objective： Opioid dependence represents a major global public health challenge， where the tolerance and addiction induced by prolonged morphine use severely restrict its clinical application. The existing anti-morphine dependence drugs demonstrated limited efficacy in alleviating physical withdrawal symptoms and psychological dependence， with high relapse rates persisting. It is urgent to develop new intervention methods through technological innovation and patent layout optimization. Methods： This study systematically analyzed the technological development trend in the field of anti-morphine dependence by constructing a search strategy within the HimmPat database， retrieving 1 921 patent families records. Results： The number of global patent applications for anti-morphine dependence peaked in 2018 followed by stabilized growth， while Chinese applications maintained steady growth， reflecting technological maturation. The United States dominates global patent coverage (35.71%) in thisfield， with China (13.01%) demonstrating significant innovative potential. Core applicants are primarily enterprises and research institutions， highlighting the need for industry-academia-research collaboration. Technologies concentrate on organic compound-based pharmaceuticals (A61K31) and neurological interventions (A61P25/36). Additionally， this study categorizes the primary technical directions and proposes development recommendations， encompassing three key areas： animal model development， device technology applications， and drug intervention therapy. Conclusion： This study provides valuable insights for optimizing research and development strategies and patent layouts in the field of anti-morphine dependence， thereby facilitating technological advancement and industrial development. Future research and development should focus on improving the clinical relevance of animal models， the precision of equipment treatment， and the stability of natural drug formulations，while deepening investigations into multi-target synergistic mechanisms.
 

Key words: Morphine, Dependence, Patent analysis, Patent layout