Abstract: [Abstract]Objective： To analyze the clinical adverse drug reactions(ADR)，and provide guidances for clinical rational drug use.Methods：729 cases of ADR collected which were monitored by the national ADR system in our hospital during the year between 2010 and 2015.And then the effective statistics，analysis and evaluation works were done with data.Results：In the 729 patients， there was 45 cases whose age were less than 18 years old， 207 cases were the age of 19 to 30 years old， 237 cases were the age of 31 to 45， 168 cases were the age of 46 to 60， 65 cases were the age of 61 to 80， and 7 cases were the age more than 80 years old;Meditation methods for 701 cases were oral medicine， 19 cases were intramuscular injection， 6 cases were intravenous injection， 2 cases were venous injection， 1 case subcutaneous injection.29 kinds of medicines were involved， among which there were 41 gauges.And there were 7 organs or systems involved， among which the nervous system damage was 520 cases， digestive system damage was 103 cases， cardiovascular system damage was 61 cases， endocrine system damage was 18 cases， immune system damage was 12 cases， blood system damage was 11 cases， urinary system damage was 4 cases.The improved outcome of adverse reactions was 571 cases (78.33%)， the recovery outcome was 158 cases(21.67%).Conclusion：The incidence of ADR in our hospital was the highest during the age of 31 to 45(32.51%)， the method of adverse reaction was mainly the oral medicine， the adverse reactions were given priority with the nervous system damage.And the risperdal was reported the most ADR. ADR monitoring and reporting should be strengthened to promote the rational use of drugs of the clinical．