胃康灵胶囊中金胺O染色物的检测方法研究

胃康灵胶囊中金胺O染色物的检测方法研究

段营辉,陈惠玲,王志林,李玲玲

厦门市食品药品质量检验研究院,厦门市食品药品质量检验研究院,泉州医药高等专科学校,厦门市食品药品质量检验研究院

收稿日期:2015-12-31 修回日期:2016-04-26 出版日期:2016-04-25 发布日期:2016-04-25

Study on Detection Methods for Auramine O in Weikangling Capsule

Xiamem Institute for Food and Drug Quality Control,,,

Received:2015-12-31 Revised:2016-04-26 Online:2016-04-25 Published:2016-04-25

摘要/Abstract

摘要： ［摘要］目的：建立胃康灵胶囊中金胺O染色物的检测方法，并对其进行筛查，同时建立阳性样品中金胺O的含量测定方法。方法：采用UPLC-PDA法对胃康灵胶囊中的金胺O进行筛查，并采用UPLC-MS/MS二级质谱对阳性样品进行确证。结果：对来自37家企业的123批次样品进行筛查和确认发现：有6家企业的23批次样品中检出金胺O；金胺O进样在0.42～208.72 ng 的范围内有良好的线性关系。胃康灵胶囊阳性样品中金胺O的含量在1.0～28.7μg?粒-1。结论：本方法准确可靠，可作为胃康灵胶囊中金胺O染色物的检测方法。

Abstract: [Abstract]Objective： To establish a method for detecting， screening and quantifying the possibly exiting auramine O in weikangling capsule.Methods：UPLC-PDA was used as a screening method for auramine O.The positive results were further confirmed by UPLC-MS/MS.Results： 123 batches of weikangling capsules from 37 manufactories were detected and confirmed： auramine O was detected from 23 batches of samples in 6 manufactories. Auramine O had considerable linear relationship in the range of 0.42~208.72 ng. The contents of auramine O in positive samples were in the range of 1.0~28.7μg per capsule. Conclusion：This method is accurate and reliable， and can be used as the detection method for auramine O in weikangling capsule.

段营辉,陈惠玲,王志林,李玲玲. 胃康灵胶囊中金胺O染色物的检测方法研究[J]. .