Abstract: Objective： To compare the dissolution profiles of cetirizine hydrochloride tablets from different manufacturers to provide information for generic drugs quality consistency evaluation. Methods： According to the dissolution test method mentioned in the Chinese Pharmacopeia 2015 edition， the dissolution behavior of three domestic cetirizine hydrochloride tablets and imported drug was investigated in water， pH 1.0 hydrochloric acid solution， pH 4.5 acetate buffer solution and pH 6.8 phosphate buffer solution. The similarity of dissolution profiles was analyzed by the f2 factor method. Results： The dissolution profiles of cetirizine hydrochloride tablets from manufacturer B were all similar to the reference preparation in four dissolution medium， but the dissolution profiles of cetirizine hydrochloride tablets from manufacturer A and manufacturer C were significantly different from that of the reference preparation. Conclusion： There was a significant difference in dissolution behavior of cetirizine hydrochloride tablets from different manufacturers. It is advised that manufacturers should improve the product quality by changing the formulation and preparation process.