Abstract: Objective： To investigate the clinical effect of Mosapride combined with Deanxit in patients with functional dyspepsia. Methods：92 patients with functional dyspepsia in Chengdu Third people′s Hospital of Xindu District were selected and divided into two groups by double blind method， observation group (n=46) treated with Mosapride plus Deanxit therapy. The control group (n=46) treated with Mosapride， compared 2 groups of patients the effect. Results：The observation group and the control group of patients with clinical total effective rate (95.65% vs 76.09%) there were obvious differences between (P<0.05). Observation group were nausea and vomiting， belching， abdominal pain and other symptoms disappeared time were lower than the control group (P<0.05). The incidence of adverse reactions in the observation group (6.52%) than in the control group (23.91%). There are obvious differences in data between the two groups (P<0.05).Conclusion： The clinical effect of Mosapride combined with Deanxit is effective， can improve the clinical effect， improve clinical symptoms， safe and effective medication.