Abstract: Objective： To investigate the clinical characteristics of fever with acute respiratory tract infection in children， to give children the clinical carativer effect of Reduning treatment. Methods： A total of 68 children were selected. The type of disease was acute respiratory infection in children with fever. The selection period was from May 2016 to April 2017. The random number table was used to divide the patients into study groups (34 patients； Reduning treatment) and control group (34 cases， ribavirin treatment). Results： The total clinical effective rate， clinical symptom disappearance time (fever and cough)， serum CRP (C reactive protein)， β2-MG (β2-microglobulin)， PA (prealbumin) and ESR (ESR) in the study group were significantly better than those in the control group， P<0.05. Conclusion： The treatment of acute toxicity infection in children with acute respiratory tract infection with Reduning， the exact effect.