Abstract: Objective： To observe the effect of tirofiban combined with percutaneous coronary intervention (PCI) on cardiac function in patients with acute ST-segment elevation myocardial infarction (STEMI). Methods：94 patients with acute STEMI treated in our hospital from June 2016 to May 2017 were selected， and they were divided into two groups by random number table， 47 cases in each group. Control group was given PCI， while observation group was treated with tirofiban based on control group. The indexes of myocardial ischemic reperfusion， incidence of adverse cardiovascular events， changes of cardiac function in two groups were observed. Results： Before treatment， there was no statistical difference in the left ventricular ejection fraction (LVEF) and left ventricular end systolic diameter (LVESD) between the two groups (P>0.05). After treatment， the LVESD of observation group was lower than that of control group， and LVEF was higher than control group (P<0.05). The rate of grade-3 TIMI blood flow， rate of ST-segment resolution>50%， incidence of adverse cardiovascular events in observation group was better than that in control group (P<0.05). Conclusion：Tirofiban combined with PCI in treatment of acute STEMI is effective， it can reduce the incidence of adverse cardiovascular events， improve myocardial perfusion and cardiac function.