Abstract: Objective：To retrospectively investigate the clinical use of enteral nutrition supplements and analyze the irrational factors， and to provide references for the optimal management of the clinical use of enteral nutrition supplements. Methods： All medical orders of enteral nutrition supplements were included in our hospital in 2017. We summarized situation of enteral nutrition use in the hospital and all departments， analyzed the number of patient-days， energy consumption and prescription daily energy (PDE). Summarized the route of administration of various enteral nutrition supplements.Results： A total of 35 009 patient-days of the use of enteral nutrition supplements were included， the top 3 supplements were TPF-D (32.76%)， TPF-T (22.65%)， and TP (14.33%). Among inpatients， in addition to TP powder， other enteral nutrition supplements are mainly administered by tube feeding. The top 3 departments of enteral nutrition supplements use are emergency and intensive care unit (11 144 patient-days)， geriatrics ward (7 291 patient-days)， and general ward (4 037 patient-days).The top 3 departments of PDE are hematology department (1 866 kcal/patient-days)， rehabilitation department (1 669 kcal/patient-days) and Digestive Department (1 522 kcal/patient-days). Moreover， there was a significant abnormality in PDE (6 374 kcal/patient-days) of TP use in the emergency and intensive care unit. Conclusion： Enteral nutrition supplements are widely used in all departments， especially the special application types. There is a significant abnormality in the use of enteral nutrition in the emergency and intensive care unit. Further studies should be conducted to analyze the irrational factors and to improve the management.