Abstract: Objective: To investigate, analysis of drug treatment of inpatients with mental disorders, and to provide reference for clinical rational drug use. Method: in December 27, 2012 for investigation, 416 cases of antipsychotic drugs in hospitalized psychiatric patients on the use of our investigation was conducted by using a method. Results: the use of atypical antipsychotic drugs in our hospital accounted for dominant position, single drug, risperidone, clozapine and quetiapine in the top three, most reasonable medication, but there are still a few unreasonable phenomenon. Conclusion: the clinician should pay attention to the safety of antipsychotic drugs, improve the level of clinical rational use of drugs, also should strengthen the investigation of drug use, timely and correct the phenomenon of irrational drug use.