Abstract: Objective: To investigate the prophylactic effect of hepatoprotectants in the treatment of lung cancer. Methods: According to the comparison of the change of transaminase between 17 patients with hepatic protectant and 32 patients without hepatic protectant, the hepatic protectant’s preventive effect has been analysed. Results: One cases (3.13%) liver function becomed unusual in 32 patients without hepatic protectant. However, 0 case (0.00%) transaminase becomed unusual in the left 17 patients with hepatic protectant，and there was not statistical difference（P＞0.05）..Conclusion: Using hepatic protectant in treatment doesn’t reduce the amount of liver damage effectually.