Abstract: Objective： To analyze the target organ and occurrencing frequency of the adverse reactions of commonly used toxic traditional Chinese medicine by retrieving literature， and provide documentary data for monitoring effectively the clinical adverse reactions. Methods： The reports and literatures of the adverse reactions of toxic traditional Chinese medicine were searched and analyzed. The target organ of toxic traditional Chinese medicine， which Chinese Pharmacopoeia records， were analyzed and collected according to category of the traditional Chinese medicine. Results： The target organ of the adverse reactions of toxic traditional Chinese medicine include gastrointestional tract， heart， liver， kidney， brain， eye， lungs， spleen， testis， ovary etc， the occurrencing frequency of which， is 30%， 21%，12%，11%，7%，7%，5%，4%，2%，0.7%，0.3%. Conclusion： It has various reasons that toxic traditional Chinese medicine has adverse reactions， and the adverse reactions is the result of multi-factor interacting. The adverse reactions could be avoided efficaciously， and the toxic traditional Chinese medicine’s safe usage could be insured by determining the reasons， characteristics and incident target organs of adverse reactions.