Abstract: Objective To detect effects of differential kinds of nutritional support therapy on nutritional status in patients with acute exacerbation of chronic obstructive pulmonary disease. Methods 556 patients with AECOPD selected randomly were retrospectively analyzed, including enteral nutrition (EN) group (36 cases), enteral combined parenteral nutrition (EN PN) group (45 cases), parenteral nutrition (PN) group (201 cases), control group (274 cases). The control group received conventional therapy, nutritional support group on this basis were given different nutritional support. The nutritional status, immunization, liver and kidney function indicators change before and after comparison of the four groups treated were observed. Results (1) nutrition and immune status: After treatment, the total protein, pre-albumin, hemoglobin of every nutritional support group significantly higher than the control group (p <0.05), in PN group the albumin and lymphocyte count than the control group was significantly higher (p <0.05); after treatment compared with PN group hemoglobin in EN group increased (p <0.05); after treatment, EN and EN PN group increased total protein compared with PN group (p<0.05). (2) liver and kidney function: For PN group after treatment ALT, AST, and CR was significantly higher than the control group (p<0.05), CR for EN PN group was significantly higher than the control group (p<0.05), for each nutritional group BUN obvious improvement than the control group (p> 0.05).