Abstract: [Abstract]Objective：To monitor the implementation of grassroots medical and health institutions in the area and the use of essential medicines， and formulate scientific and rational essential medicines promotion policies. Methods：In the form of the questionnaire to collect grassroots medical and health institutions in before and after the implementation of the system for basic drugs， basic drugs equipped with the use of reimbursement， and 2 counties， 4 grassroots medical and health institutions prescription checks. Results：After the full implementation of the essential medicines system， the city's 92 grassroots medical and health institutions and 1095 village health station 100% with the use of essential medicines， 100% implementation zero slip sales and 100% into the medicare reimbursement. Prior to the implementation of the contrast month， basic medical and health institutions outpatient quantity increase 26.52%， amount of hospitalization reduced 32.57%， outpatient and emergency department second all expenses for medicine by 7.49%， average hospitalization expenses reduced 13.76%， drug income reduction of 2.88%. On average， the average use of essential medicines was less than 5 types， the use of antibiotics was 57.5%， the proportion of the use of the hormone was 17.5%， the use of injection was 60%， the average amount of single prescription was 34.12 yuan. Conclusion：The essential medicines system implementation reasonable guide patients first diagnosed at the grassroots level， reduce the economic burden of the patients， but must to have a scientific and reasonable compensation mechanism and performance appraisal system to support the normal operation of grassroots medical and health institutions， at the same time to strengthen the propaganda and training system for essential medicines and rational drug use， guide the grassroots doctors in the proper use of essential medicines.