• 中国核心期刊(遴选)数据库收录期刊
  • 中文科技期刊数据库收录期刊
  • 中国期刊全文数据库收录期刊
  • 中国学术期刊综合评价数据库统计源期刊等

• 评价技术与方法 •    下一篇

ICP-MS法测定贞芪扶正颗粒中5种重金属的含量

周凌,鄢长余,张静娇,赵月然,胡景莲   

  1. 大连市药品检验所,大连市药品检验所,大连市药品检验所,大连市药品检验所,大连市药品检验所
  • 收稿日期:2016-01-10 修回日期:2016-02-21 出版日期:2016-04-25 发布日期:2016-04-25

ICP-MS Method for the Determination of 5 Kinds of Heavy Metals in Zhenqi Fuzheng Granules

  1. Dalian Institute for Drug Control,,,,
  • Received:2016-01-10 Revised:2016-02-21 Online:2016-04-25 Published:2016-04-25

摘要: [摘 要]目的: 采用电感耦合等离子体质谱(ICP-MS)法测定111批贞芪扶正颗粒中As、Cd、Pb、Hg、Cu 5种重金属的含量,全面评估重金属在成方制剂中的残留量。方法:样品经微波消解,As、Cu以Ge作为内标,Hg、Pb以Bi作为内标,Cd以In为内标,采用ICP-MS法同时测定该5种元素。结果:对于所测元素,校准曲线的相关系数r均大于0.999,111批贞芪扶正颗粒的As、Cd、Pb、Hg、Cu 5种重金属的含量均在可控范围内。结论:本实验方法准确可行,为今后成方制剂中重金属残留量的控制提供了方法和数据参考。

Abstract: [Abstract]Objective: Using inductively coupled plasma-mass spectrometry(ICP-MS) method to determinate 5 kinds of heavy metals content about As, Cd, Pb, Hg, Cu in 111 batches of zhenqi fuzheng granules, evaluating comprehensively heavy metal residues in drugs preparation. Methods: Sample by microwave digestion, As, Cu with Ge as an internal standard, Hg, Pb with Bi as an internal standard, Cd with In as an internal standard, using icp-ms method determinated 5 elements. Results: About the measured elements, correlation coefficient r of the calibration curve were greater than 0.999, 5 kinds of heavy metals content about As, Cd, Pb, Hg, Cu in 111 batches of zhenqi fuzheng granules are under control. Conclusion: This method is accurate and feasible. Heavy metal residues in preparation for the next square control provides methods and data reference.