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对药品中芦荟苷含量测定的改进建议

吴旭   

  1. 淮安市食品药品检验所
  • 收稿日期:2018-08-21 修回日期:2018-08-21 出版日期:2018-12-25 发布日期:2018-12-25

Simultaneous Determination of Gallic Acid and Chlorogenic Acid in Golden Throat Lozenge by HPLC-PDA

WU Xu   

  1. Huai''an Institute for Food and Drug Control
  • Received:2018-08-21 Revised:2018-08-21 Online:2018-12-25 Published:2018-12-25

摘要: 目的:对目前我国药品中测定芦荟苷含量时遇到的问题进行研究并提出相关建议。方法:采用HPLC-MS/MS法,对HPLC法测定芦荟苷含量时所遇到的问题进行研究分析。结果:现有的芦荟苷含量测定仅测了芦荟苷A的含量,而芦荟苷是芦荟苷A和芦荟苷B的混合体,有些药品因此含量不合格。结论:建议对药品中芦荟苷的含量测定方法进行进一步的深入研究,从而完善检测标准。

Abstract: Objective: To explore the problems encountered in the determination of barbaloin in Chinese medicines and then we put forward some suggestions. Methods:The problems encountered in the determination of barbaloin by HPLC-MS/MS were studied and analyzed. Results: Barbaloin was a mixture of barbaloin A and barbaloin B, but barbaloin A was only detected in the existing assays. So some drugs were unqualified. Conclusion: It is suggested that the determination method of barbaloin in medicines should be further studied to improve the detection ability and quality standard.