Abstract: Objective： To study the correlation between CysC and LP-PLA2 and lower limb vascular lesions in type 2 diabetes mellitus. Methods： Research object selection from August 2016 to March 2019 were 60 cases of patients with type 2 diabetes， according to the random method according to its ankle brachial index (ABI) into the not associated with type 2 diabetes lower limb vascular lesion group (without disease group) 30 cases， with type 2 diabetes lower limb vascular lesion group (with the lesion group)， 30 cases in the same period choose healthy check-up 30 cases as control group. Serum CysC， LP-PLA2， serum lipid and glycosylated hemoglobin levels of the three groups were compared， and the correlation was analyzed by Pearson linear correlation analysis. Results： Serum CysC， LP-PLA2， TC， TG， ldl-c and glycosylated hemoglobin levels in the group with pathological changes were significantly higher than those in the group without pathological changes and the control group (P<0.05). The serum hdl-c level of the group with lesions was significantly lower than that of the group without lesions and the control group (P<0.05)， while that of the group without lesions was lower than that of the control group (P<0.05). Pearson linear correlation analysis showed that serum CysC and LP-PLA2 were closely correlated with lower limb vascular lesions in type 2 diabetes mellitus (P<0.05). Conclusion： Serum CysC and LP-PLA2 were significantly expressed in lower limb vascular lesions of type 2 diabetes mellitus， showing a significant correlation， which is of great significance for clinical diagnosis and treatment.