Abstract: Objective：To observe the clinical efficacy of interferon alpha 1b combined with ribavirin in the treatment of hand， foot and mouth disease in children. Methods： A Chinese National Knowledge Infrastructure(CNKI)， Wanfang Database and VIP Database (VIP) were searched for randomized controlled trials of interferon alpha 1b combined with ribavirin in the treatment of hand， foot and mouth disease in children. The search time was established for the database until Sep.2019. The quality evaluation and data extraction of the included studies were independently and strictly conducted by two investigators， and Meta analysis was performed using Revman 5.3 software. Results： A total of 1 793 children with hand， foot and mouth disease were included in 11 RCTs. Meta-analysis results showed that：Interferon α1b combined with ribavirin in the treatment of children with hand， foot and mouth disease in terms of efficiency， fever time， rash regression time， oral herpes regression time， healing time compared with the control group， both have statistics Significance (P<0.05). Conclusion： Interferon α1b combined with ribavirin has a certain curative effect in the treatment of hand， foot and mouth disease in children. However， the quality of existing research is low， and more rigorous high-quality， multi-center randomized double-blind clinical studies are needed to further verify.