关键词: Meta分析, 2型糖尿病, 六味地黄丸, 中西医结合疗法, 随机对照试验

Abstract: Objective：To systematically evaluate therapeutic efficacy and safety of liuweidihuang decoction combined with different conventional treatmentsfor type 2 diabetes mellitus and explainthe curative effect of liuweidihuang decoction. Methods： Four Chinese databases(CNKI， VIP， WanFang Data， CBM)andthree English databases (PubMed， Embase and Cochrane Library) are searched systematically from January 1，2017 to August 19， 2019 for Chinese literature and For English literature， the time is from January 1，2009 to August 19， 2019， to collect the randomized controlled trials (RCTs) about the treatment of Liuweidihuang decoction for type 2diabetes mellitus.Two investigators independently performed literature screening， data extraction and bias risk assessment.RevMan 5.3 software was used for data analysis. Finally 281 literaturewere retrieved and 16 studies were included in this study， involving 1 743 patients. Results： Meta-analysis results showed that in the total clinical effective rate， liuweidihuang decoction combined with conventional treatment was superior to conventional treatment[Rr=1.24，95%CI（1.19，1.29）， P＜0.000 01]， meanwhile， in decreasing fasting plasma glucose（FBG）[MD=-0.45，95%CI（-0.62，-0.27），P＜0.000 01]，glycosylated hemoglobin (HbA1C)[MD=-0.41，95%CI（-0.58，-0.24），P＜0.000 01]. Conclusion：It is efficacy and safety that theLiuweidihuangdecoctioncombined with different conventional treatmentsfor type 2 diabetes mellitus. And there is no statistically significant difference between different studies， so it is effective in treating type 2 diabetes mellitusandis not affected by the type of conventional treatment. But the overall quality of the included studies was generally lowquality， the conclusion still needs more high-quality， multi-center randomized triple-block controlled trials to verify.

Key words: Meta-analysis, Type 2 diabetes mellitus, Liuweidihuang decoction, Combined therapy of Chinese and Western medicine, Randomized controlled trail (RCT)