关键词: font-size:medium, ">生脉注射液；电感耦合等离子体质谱；重金属及有害元素；SPSS统计分析

Abstract: Objective： To establish a determination of Pb、Cd、As、Hg、Cu in ShengmaiInjection.Methods：Using Ge、In、Bi as the internal standard to determined 5 kinds of element at the sametime by ICP-MS. SPSS statistical analysis software was used to analysis and evaluate the samples from different manufacturers and different batches. Results：The standard curve correlation coefficients of determined elements were all greater than 0.997，the average rates of recovery were from 82% to 105%，and the relative standard deviation(RSD)was less than 8.9%.Cr and Hg were significantly correlated with each other and the Pearson correlation coefficient was 0.848. In addition， As and Pb， As and Cd contents were also respectively correlated， and the Pearson correlation coefficients were 0.683 and 0.686. P value of the above statistical results were less than 0.01 (with significant significance). Conclusion：The method is accurate， rapid and simple. It can be used for the quality control of heavy metals and harmful elements in Shengmai injection. It can also be used as an auxiliary reference for the lateral evaluation of the quality of the drugs produced by the manufacturers.

Key words: font-size:medium, ">Shengmai injection；ICP-MS； Heavy metals and hazard elements； SPSS statistical analysis