关键词: font-size:medium, ">卡贝；缩宫素；高危产妇；剖宫产术；凝血功能；不良反应

Abstract: Objective： To evaluate the preventive effect and coagulation function of carbetocin in high-risk maternal cesarean section during and after cesarean section. Methods： The clinical data of 70 high-risk cesarean delivery women admitted to the hospital from October 2016 to October 2019 were retrospectively analyzed. According to the different treatment options for patients， they were divided into Kabe group and oxytocin group. Compare the bleeding situation， the third stage of labor， hemoglobin level， blood pressure， heart rate of the two groups of patients after 2 hours of operation and 24 hours after operation. Indexes of coagulation function in different periods of time after delivery of women： prothrombin time (PT)， thrombin time (APTT)， fibrinogen (FIB) and incidence of adverse reactions. Results： In terms of bleeding volume and bleeding rate， the 2 h and the 24 h after the cesarean section were significantly lower than those in the oxytocin group (P<0.05). The difference in bleeding rate between the two groups after treatment was not the same. Significantly (P>0.05). In terms of physiological parameters， hemoglobin level， systolic blood pressure (SBP)， diastolic blood pressure (DBP) and heart rate were not significantly different (P>0.05)， postoperative medication 24 h. The hemoglobin level and systolic blood pressure (SBP) of the Kabe group were significantly higher than those of the oxytocin group (P<0.05). In the coagulation function， the FIB of the Kabe group was significantly higher than that of the oxytocin group 24 h after the administration(P<0.05). The coagulation function indexes of the two groups were not significantly different (P>0.05)； the third stage of the Kabe group was significantly lower than the oxytocin group (P<0.05)， the total incidence of adverse reactions in the two groups. The difference was not significant (p>0.05). Conclusion： Carbetocin can reduce the amount of bleeding during and after cesarean section in high-risk women， and improve its coagulation function， which has important clinical application value for ensuring postoperative life safety.

Key words: font-size:medium, ">Carbe； Oxytocin； High-risk Maternal； Cesarean Section； Coagulation function； Adverse reactions