关键词: font-size:medium, ">药物性肝损伤；临床分析；预后；影响因素

Abstract: Objective： To analyze the clinical data of hospitalized patients with drug-induced liver injury (DILI) in recent 5 years and explore the prognostic factors. Methods： Clinical data of DILI inpatients in a hospital in the past 5 years were retrospectively analyzed，univariate and multivariate Logistic regression analysis were out on the factors of patients′ age， gender， basic diseases， implicated drugs types and administration routes， clinical manifestations， biochemical indicators， clinical typing and length of stay. Results： The results of univariate analysis showed that occupation， basic disease， route of administration， initial ALP， initial AST， initial GGT， initial TBIL， ALT peak， ALP peak， AST peak， GGT peak， TBIL peak， ALB peak， WBC peak and PLT peak had statistically significant effects on the prognosis of DILI patients (P<0.05). Multivariate Logistic regression analysis showed that the unemployed， Chinese medicine， GGT peak were negatively correlated with prognosis of patients. (P<0.05).Respiratory and digestive diseases， initial TBIL， initial GGT， peak ALB and peak WBC were positively correlated with the prognosis of patients (P<0.05). Conclusion： When the unemployed and the implicated drugs are traditional Chinese medicine， the prognosis of the patients is poor. The GGT peak is higher， the prognosis of the patients is worse. When the underlying diseases are respiratory and digestive diseases and the ALB peak is higher， the prognosis is better.

Key words: font-size:medium, ">Drug-induced liver injury； Clinical analysis； Prognosis； Influence factors