关键词: font-size:medium, ">伏立康唑；侵袭性真菌病；临床疗效；影响因素

Abstract: Objective： To evaluate the clinical efficacy of Voriconazole in the treatment of invasive fungal diseases and to explore the related factors. Methods： Retrospective analysis was performed on the clinical data of inpatients diagnosed with invasive fungal disease who were given voriconazole on January 1， 2018 and December 31， 2018 in hospital. The clinical efficacy of voriconazole in the treatment of invasive fungal disease was evaluated and the influencing factors were analyzed by univariate and multivariate Logistic regression. Results：The site of infection in the lungs was 74.53% in 96 patients.The total effective rate of clinical treatment was 63.54%.The results of univariate analysis showed that the length of hospital stay， the number of days of voriconazole use and the combination of hypoproteinemia were the factors affecting the efficacy of Voriconazole (P<0.05).Multivariate Logistic regression analysis showed that the number of days of use was the protective factor affecting the curative effect of Voriconazole， and hypoproteinemia was the risk factor affecting the curative effect of Voriconazole. Conclusion： Voriconazole has a good curative effect in the treatment of invasive fungal diseases. The course of clinical treatment should be sufficient. Hypoproteinemia affects the prognosis of patients and the clinical treatment should be timely corrected.
 

Key words: font-size:medium, ">Voriconazole； Invasive fungal disease； Clinical efficacy；Influence factors