• 中国核心期刊(遴选)数据库收录期刊
  • 中文科技期刊数据库收录期刊
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中国药物评价 ›› 2021, Vol. 38 ›› Issue (2): 130-132.

• 药品评价 • 上一篇    下一篇

806例严重药品不良反应/事件回顾性分析

  李蓓   

  1. 哈尔滨市药品不良反应监测中心, 黑龙江 哈尔滨 150016
  • 收稿日期:2021-02-01 修回日期:2021-02-19 出版日期:2021-04-28 发布日期:2021-04-28

Retrospective Analysis of 806 Cases of Severe Adverse Drug Reactions/Events

   LI Bei   

  1. Harbin Center for ADR Monitoring,Heilongjiang Harbin 150016, China
  • Received:2021-02-01 Revised:2021-02-19 Online:2021-04-28 Published:2021-04-28

摘要: 目的:分析严重药品不良反应/事件(ADR/ADE)报告的发生规律和特点,为临床合理用药提供信息。方法:对806例严重ADR/ADE报告进行汇总,分别从患者性别、药品种类、年龄、累及系统-器官、给药途径及不良反应转归等方面进行统计分析。结果: 严重ADR/ADE患者中女性与男性比例为1∶0.91,≥60岁患者占比69.98%。涉及药品品种例次最多的为抗感染药物、中药成方和肿瘤用药(分别占比37.20%、12.40%和9.92%)。严重ADR/ADE给药途径以静脉给药为主,累及系统-器官主要表现为皮肤及附件损害,全身性损伤及心血管系统。结论: 应加强抗感染药、中药制剂及抗肿瘤用药的监测,尤其加强注射制剂及重点人群的用药监测。
  

关键词: font-size:medium, ">严重药品不良反应/事件;合理用药

Abstract: Objective: The occurrence and characteristics of severe adverse drug reactions (ADR/ADE) were analyzed, to provide information for rational drug use in clinic. Methods: The reports of 806 severe ADR/ADE cases were summarized,statistical analysis was carried out from such aspects patient gender, drug type, age, systemic involvement-organ involvement, route of administration and outcome of adverse drug reactions. Results: The ratio of women to men in severe ADR/ADE was 1∶0.91, percentage of patients 60 or older 69.98%. The most common drugs involved were anti-infective drugs,prescription of traditional Chinese medicine and administration of Tumor Drugs(respective share 37.20%, 12.40%, 9.92%). Ntravenous administration is the main route of administration, serious ADR/ADE involved the system-organ mainly showed skin and appendage damage, general injury and the cardiovascular system. Conclusion: Surveillance of anti-infective agents, traditional Chinese medicine preparation and antineoplastic drugshould be strengthened, in particular, to strengthen the injection preparations and key populations of drug monitoring.

Key words: font-size:medium, ">Severe ADR/ADE; Rational use of drugs

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