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中国药物评价 ›› 2021, Vol. 38 ›› Issue (2): 138-140.

• 药品评价 • 上一篇    下一篇

注射用尖吻蝮蛇血凝酶与复方右旋糖酐40注射液连续输注致严重过敏样反应1例

王威丽1,2, 赵玉林1, 张阳1, 宋沧桑1,2*   

  1. 1. 昆明市第一人民医院药学部, 云南 昆明 650000;
    2. 大理大学药学院, 云南 大理 671000
  • 收稿日期:2021-01-11 修回日期:2021-03-18 出版日期:2021-04-28 发布日期:2021-04-28
  • 基金资助:
    云南省卫生科技计划项目(项目名称:临床药师参与精准药学服务在华法林抗凝治疗中的作用研究,项目编号:2018NS0169) 

A Case of Severe Allergic Reaction Caused by Continuous Infusion of Hemagglutinin and Compound Dextran 40 Injection

WANG Wei-li1,2, ZHAO Yu-lin1, ZHANG Yang1, SONG Cang-sang1,2*   

  1. 1. Kunming First People′s Hospital Department of Pharmacy, Yunnan Kunming 650000, China;
    2. College of Pharmacy, Dali University, Yunnan Dali 671000, China
  • Received:2021-01-11 Revised:2021-03-18 Online:2021-04-28 Published:2021-04-28
  • Contact: Sang CangSONG E-mail:songcs163@163.com

摘要: 目的:通过对1例注射用尖吻蝮蛇血凝酶与复方右旋糖酐40注射液连续输注致严重过敏样反应的病例进行分析,探讨其发生变态反应的原因,为临床安全用药提供参考。方法:采用回顾性方法分析该病历的诊治过程,结合国内外文献,对其诱发严重过敏样反应的关联性及发生机制进行探讨。结果: 连续输注注射用尖吻蝮蛇血凝酶与复方右旋糖酐40注射液可能会引起严重过敏样反应,其原因与二者均具有强抗原性密切相关。结论: 提示广大临床医务人员应高度重视药品连续输注所产生的不良反应,保障患者临床用药的安全性与有效性。

关键词: font-size:medium, ">注射用尖吻蝮蛇凝酶;复方右旋糖酐40注射液;药品不良反应;连续输注

Abstract: Objective:Through the analysis of a case of severe allergic reaction caused by continuous infusion of hemagglutinin and compound dextran 40 injection for injection, the causes of adverse reactions were discussed, which provided reference for rational and safe clinical use of drugs. Methods: The diagnosis and treatment process of the real medical record was analyzed retrospectively, and the correlation, mechanism and attention of the allergic reaction were discussed. Results: The hemagglutinin of Agkistrodon halys for continuous infusion and compound dextran 40 injection may cause severe allergic reaction, which is closely related to both of them. Conclusion: It is suggested that the majority of clinical medical staff should attach great importance to the adverse reactions caused by continuous infusion of two drugs to ensure the safety and effectiveness of clinical medication.
   

Key words: font-size:medium, ">Haemocoagulase agkistrodon; Compound dextran 40 injection; Adverse drug reactions; Continuous infusion

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