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中国药物评价 ›› 2021, Vol. 38 ›› Issue (3): 196-201.

• 评价技术与方法 • 上一篇    下一篇

火焰光度法测定人血白蛋白中钠离子含量的 不确定度评定

  庞赛, 庞发根, 刘晶晶, 李玉兰*, 王铁杰   

  1. 深圳市药品检验研究院, 深圳市药品质量标准研究重点实验室, 广东 深圳 518057
  • 收稿日期:2021-01-05 修回日期:2021-05-06 出版日期:2021-06-28 发布日期:2021-06-28

Evaluation of Measurement Uncertainty for the Etermination of Sodium Ion Content of Human Albumin by Flame Atomic Absorption Spectrometry

  1. Shenzhen Institute for Drug Control, Shenzhen Key Laboratory of Drug Quality Standard Research, Guangdong  Shenzhen 518057, China
  • Received:2021-01-05 Revised:2021-05-06 Online:2021-06-28 Published:2021-06-28
  • Contact: Yulan LI E-mail:981230481@qq.com

摘要: 目的:建立火焰光度法测定人血白蛋白中钠离子含量的不确定度评定方法,探讨影响钠离子含量测定的不确定度分量。方法: 对火焰光度法测定人血白蛋白中钠离子含量的全过程进行分析,建立不确定度的数学模型,分析测量不确定度的来源并对各分量进行量化分析和评估,合成标准测量不确定度,给出扩展测量不确定度报告。结果: 火焰光度法测定人血白蛋白中钠离子含量为133 mmol·L-1,其扩展不确定度为3 mmol·L-1,测量结果表示为(133±3)mmol·L-1(k=2)。结论: 建立了火焰光度法测定人血白蛋白中钠离子含量的测量不确定度评定方法,分析产生不确定度的主要来源,为有效控制钠离子含量测定方法的准确性提供可靠依据。

关键词: font-size:13.3333px, ">火焰光度法;人血白蛋白;钠离子含量;不确定度评定

Abstract: Objective: To establish an uncertainty evaluation method for the determination of Sodium Ion in Human Albumin by flame atomic absorption spectrometry, and to identify the factors affecting the uncertainty. Methods: The measurement model was established according to the detection process. The uncertainty sources were analyzed. Component involved in the uncertainty were calculated, Standard uncertainty was combined and the expanded uncertainty was obtained. Results: The results showed that the Sodium Ion content in Human Albumin was 133 mmol·L-1, and the expanded uncertainty was 3 mmol·L-1, and the determination result was (133±3) mmol·L-1, k=2. Conclusion: The method of the uncertainty evaluation for the determination of Sodium Ion content in Human Albumin by flame atomic absorption spectrometry method is established. The main sources of uncertainty are analyzed. This research provides a reliable theoretical basis for effectively controlling the accuracy of the determination method of sodium ion content.
 

Key words: font-size:13.3333px, ">Flame atomic absorption spectrometry; Human Albumin; Sodium Ion content; Measurement uncertainty

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