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中国药物评价 ›› 2021, Vol. 38 ›› Issue (5): 445-448.

• 药品评价 • 上一篇    下一篇

长期使用羧甲司坦对支气管扩张患者急性发作频率和持续时间的影响

     祖翡翠   

  1. 郑州大学附属郑州中心医院, 河南 郑州 450000
  • 收稿日期:2021-09-02 修回日期:2021-09-22 出版日期:2021-10-28 发布日期:2021-10-28

Effects of Long-term Use of Carboxymethylstine on the Frequency and Duration of Acute Episodes in Patients with Bronchiectasis

  1. Zhengzhou Central Hospital of Zhengzhou University, Henan Zhengzhou 450000, China
  • Received:2021-09-02 Revised:2021-09-22 Online:2021-10-28 Published:2021-10-28

摘要: 目的:评估长期使用羧甲司坦对支气管扩张患者急性发作频率和持续时间的影响。方法:回顾性分析 2018年 8 月1日至2020年 8 月30日入院的200例支气管扩张患者:一组100例接受羧甲司坦治疗超过3个月的支气管扩张患者(观察组EG)和另一组100例在同一时期未接受羧甲司坦治疗的支气管扩张患者(对照组CG)之间的恶化频率和持续时间。比较两组患者培养出流感嗜血杆菌、卡他性白菌、肺炎链球菌、铜绿假单胞菌及其他细菌的人数,比较两组患者支气管扩张3个月内平均发作次数、平均恶化持续时间、上腹痛、恶心呕吐、腹泻、头痛等发病情况。结果:观察组培养出流感嗜血杆菌10例、卡他性白菌11例、肺炎链球菌9例显著低于对照组培养出流感嗜血杆菌20例、卡他性白菌22例、肺炎链球菌19例,差异具有统计学意义(P<0.05)。观察组培养出铜绿假单胞菌17例、其他细菌13例与对照组培养出气绿假单胞菌25例、其他细菌10例对比无统计学差异(P>0.05)。观察组未分离出细菌40例显著高于对照组未分离出细菌4例,差异具有统计学意义(P<0.05)。观察组3个月内平均发作(7.41±0.87)次、平均恶化持续(4.45±0.86)天显著低于对照组3个月内平均发作(17.44±1.35)次、平均恶化持续(18.01±0.56)天,差异具有统计学意义(P<0.05)。观察组不良反应发生率上腹痛4%、恶心呕吐6%、腹泻4%、头痛5%显著低于对照组不良反应发生率上腹痛15%、恶心呕吐18%、腹泻19%、头痛17%,差异具有统计学意义(P<0.05)。结论:羧甲司坦对支气管扩张患者的急性发作频率和持续时间具有积极作用,并且具有良好的耐受性。
  

关键词: font-size:medium, ">羧甲司坦;支气管扩张;急性发作;持续时间

Abstract: Objective: To evaluate the effects of long-term use of carboxymethylstine on the frequency and duration of acute attacks in patients with bronchiectasis. Methods: Retrospective analysis was performed on 200 patients with bronchiectasis hospitalized from August 1, 2018 to August 30, 2020: The frequency and duration of deterioration between a group of 100 bronchiectasis patients who received carboxymethylstane for more than three months (observation group EG) and another group of 100 bronchiectasis patients who did not receive carboxymethylstane during the same period (control group CG). The number of patients cultured with Haemophilus influenzae, B. catarrh, Streptococcus pneumoniae, Pseudomonas aeruginosa and other bacteria were compared between the two groups. The average number of bronchiectasis attacks within 3 months, average duration of deterioration, upper abdominal pain, nausea and vomiting, diarrhea and headache were compared between the two groups. Results: In the observation group, 10 cases of Haemophilus influenzae, 11 cases of C. catarrhae and 9 cases of Streptococcus pneumoniae were significantly lower than those in the control group, 20 cases of H. influenzae, 22 cases of C. catarrhae and 19 cases of S. pneumoniae, the differences were statistically significant (P<0.05). 17 cases of Pseudomonas aeruginosa and 13 cases of other bacteria were cultured in the observation group, while 25 cases of pseudomonas aeruginosa and 10 cases of other bacteria were cultured in the control group (P>0.05). The 40 cases in the observation group were significantly higher than the 4 cases in the control group, the difference was statistically significant (P<0.05). The average number of attacks and the average duration of deterioration in the observation group were (7.41±0.87) days and (4.45±0.86) days, respectively, significantly lower than those in the control group (17.44±1.35) months and (18.01±0.56) days, with statistically significant differences (P<0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the control group (upper abdominal pain (4%), nausea and vomiting (6%), diarrhea (4%) and headache (5%), with statistical significance (P<0.05). Conclusions: Carboxymethylstine has a positive effect on the frequency and duration of acute attacks in patients with bronchiectasis and is well tolerated.
  

Key words: Carboxymethylstine, Bronchiectasis, Acute Episodes, Duration

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