垂体后叶素联合卡前列素氨丁三醇治疗胎盘早剥产后出血的Meta分析

摘要/Abstract

摘要： 目的：系统评价垂体后叶素联合卡前列素氨丁三醇治疗胎盘早剥产后出血的临床疗效。方法：计算机检索CBM、CNKI、WanFang Data、VIP以及PubMed、The Cochrane Library、EMbase等数据库中收录的垂体后叶素联合卡前列素氨丁三醇治疗胎盘早剥产后出血的随机对照试验（RCT）,检索时间截至2021年5月，根据纳入和排除标准提取数据。应用Rev Man 5.3和Stata 15.0软件进行Meta分析。结果：共纳入21项研究，1 580例患者。Meta分析结果显示：联合组第三产程时间［SMD=-2.88,95%CI（-3.07,-2.68）］、止血时间［SMD=-1.64,95%CI（-1.99,-1.30）］、产后30 min出血量［SMD=-11.85,95%CI（-18.54,-5.16）］、产后24 h出血量［SMD=-9.59,95%CI（-11.58,-7.60）］明显少于对照组；不良事件发生情况：联合组的产后输血率［RR=0.12,95%CI（0.05,0.28）］、子宫切除率［RR=0.24，95%CI（0.15,0.39）］、新生儿窒息率［RR=0.28,95%CI（0.20,0.40）］、新生儿死亡率［RR=0.16,95%CI（0.07,0.37）］均低于对照组，差异均有统计学意义。结论：垂体后叶素联合卡前列素氨丁三醇治疗胎盘早剥产后出血的疗效确切，可为临床用药提供参考。

关键词: font-size:medium, ">垂体后叶素；卡前列素氨丁三醇；胎盘早剥；产后出血；Meta分析

Abstract: Objective：To systematically evaluate the clinical efficacy of Pituitrin combined with carboprost tromethamine in the treatment of postpartum hemorrhage of placental abruption. Methods：Retrieved from CNKI, Wan Fang Data, CBM and VIP, Pub Med, EMbase, Web of Science and The Cochrane Library database，randomized controlled trials （RCTs） about Pituitrin combined with carboprost aminobutyriol in treating postpartum hemorrhage of placental abruptionwere collected during the inception to May 2021.Extract data according to inclusion and exclusion criteria. Revman 5.4 and Stata 15.0 software was used for meta-analysis.Results：Totally 21 studies involving 1580 patients were included.Meta-analysisdisplayed that the time of the third stage of labor［SMD=-2.88, 95%CI（-3.07,-2.68）］,the time of stopping bleeding［SMD=-1.64, 95%CI（-1.99,-1.30）］,the amount of postpartum 30min bleeding［SMD=-11.85, 95%CI（-18.54,-5.16）］, 24 hours postpartum hemorrhage［SMD=-9.59, 95%CI（-11.58,-7.60）］，Postpartum blood transfusion rate［RR=0.12，95%CI（0.05,0.28）］, hysterectomy rate［RR=0.24, 95%CI（0.15,0.39）］, neonatal asphyxia rate［RR=0.28, 95%CI（0.20,0.40）］ and neonatal mortality rate［RR=0.16, 95%CI（0.07,0.37）］in combination group were significantly lower than control group, and the differences were statistically significant.Conclusion：Pituitrin combined with carboprost tromethamine is effective in the treatment of postpartum hemorrhage of placental abruption, which provides basis and reference for clinical medication.

Key words: Pituitrin, Carboprostaminobutyriol, Placenta abruptio, Postpartum hemorrhage, Meta-analysis

中图分类号:

廖思, 华鹏, 缪菊连, 谢晓青, 王瑞航, . 垂体后叶素联合卡前列素氨丁三醇治疗胎盘早剥产后出血的Meta分析[J]. 中国药物评价, 2022, 39(1): 64-71.

LIAO Si, HUA Peng, MIAO Ju-lian , XIE Xiao-qing , WANG Rui-hang, . Meta-analysis of Pituitrin Combined with Carboprost Aminobutyriol in Treating Postpartum Hemorrhage of Placental Abruption[J]. CHINESE JOURNAL OF DRUG EVALUATION, 2022, 39(1): 64-71.

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