关键词: 儿童肺炎；支原体；大环内酯类, 阿奇霉素

Abstract: Objective：To summarize the clinical characteristics of children with MPP who did not respond to azithromycin. Methods: The clinical data of 259 children with MPP were retrospectively analyzed. According to their response to azithromycin treatment， they were divided into "effective" and "ineffective" group. Their clinical manifestations， laboratory tests and complications were compared. Results： There were 218 cases in the effective group and 41 cases in the ineffective group. The duration of heat in the ineffective group(13.34±5.41 d) was significantly higher than that in the effective group(13.34±5.41 d)， and the length of hospital stay(16.07±7.43 d) was longer than that in the effective group(8.53±1.90 d). Compare the two groups of CRP， SF， interleukin-6， LDH， D-D were significantly higher than the effective group. While the WBC and procalcitonin there was no difference between the two groups. The complications of rash， liver injury， embolism， bronchitis obliterans， pleural effusion and mucous membrane necrosis under fibrobronchoscopy were significantly higher in the azithromycin ineffective group. Conclusion： The levels of CRP， interleukin-6， SF， LDH and D-D in children with MPP who did not respond to azithromycin treatment were significantly higher than those in the effective group， and the common complications were significantly higher than those in the effective group.

Key words: Children Pneumonia, Mycoplasma, Macrolides；Azithromycin