IL-33/ST2信号通路在过敏性疾病中的作用机制及中医药干预机制研究进展

摘要/Abstract

摘要： IL-33作为IL-1家族的成员，在免疫及过敏性疾病中发挥重要作用。研究显示，其通过与其受体ST2结合，激活多种炎性细胞及信号通路，在多种疾病中发挥重要作用。本文就IL-33及其受体ST2在免疫及过敏性疾病中的作用机制的研究进展进行综述，并对文献报道的治疗过敏性疾病的中药复方对IL-33/ST2通路的作用机制进行整理分析，以期为临床治疗相关疾病提供依据和方法。

关键词: font-size:medium, ">白细胞介素-33；ST2；过敏性鼻炎；作用机制

Abstract: Allergic rhinitis (AR) is a non-infectious chronic inflammatory disease of the nasal mucosa caused by exposure of an atopic individual to an allergen. As a member of the IL-1 family，IL-33 plays an important role in allergic rhinitis by binding to its receptor ST2 after activation of allergens such as pollen. This article reviews the research progress of IL-33 and its receptor ST2 in AR， and analyzed the mechanism of IL-33/ST2 pathway used of traditional Chinese medicine compound in allergic diseases.

Key words: font-size:medium, ">Interleukin-33；ST2；Rhinallergosis；Mechanism of action

中图分类号:

张玮, 王甜, 初晓艺, 王丽丽, 唐丽. IL-33/ST2信号通路在过敏性疾病中的作用机制及中医药干预机制研究进展[J]. 中国药物评价, 2022, 39(5): 399-405.

ZHANGWei, WANG Tian, CHU Xiao-yi, WANG Li-li, TANG Li. Research Progress on Pathological Mechanism of Seasonal Allergic Rhinitis and its Chinese Medicine Therapeutic Mechanism[J]. CHINESE JOURNAL OF DRUG EVALUATION, 2022, 39(5): 399-405.

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