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中国药物评价 ›› 2022, Vol. 39 ›› Issue (6): 451-455.

• 药物研究 • 上一篇    下一篇

大鼠肠道菌群介导的辛伐他汀与抗菌药物之间的药物相互作用

吴怡 1, 毛勇1, 王丽媛1, 方甜甜2*, 刘德华2, 罗欣喜3   

  1. 1.昆明医科大学, 云南 昆明 650500;  2.昆明市第一人民医院, 云南 昆明 650031; 3.昆明学院, 云南 昆明 650214
  • 收稿日期:2022-08-31 出版日期:2022-12-28 发布日期:2022-12-28
  • 基金资助:
    云南省教育厅科学研究基金项目(No. 2019J1295);昆明市科技局项目(No. 2019KJJH073);昆明市卫生科技人才培养项目(No.2020-SW(后备)-36)

Drug Interactions between Simvastatin and Antibiotics Mediated By Intestinal Microbiota In Rats

  1. 1.Kunming Medical University, Yunnan Kunming 650500, China;  2.Kunming First People′s Hospital,Yunnan Kunming 650031, China;  3.Kunming University, Yunnan Kunming 650214, China
  • Received:2022-08-31 Online:2022-12-28 Published:2022-12-28

摘要: 目的:探讨辛伐他汀和抗菌药物之间的药物相互作用是否与大鼠肠道菌群有关。方法:选取临床常用的3种口服抗菌药物头孢克洛干混悬剂、阿奇霉素干混悬剂和阿莫西林克拉维酸钾颗粒,将SD大鼠随机分为头孢克洛组、阿奇霉素组、阿莫西林克拉维酸钾组与空白组。按照给药方案灌胃给药,制备大鼠肠道菌液,经高压灭菌与不灭菌两种处理后加入等量辛伐他汀与肠道菌群液共培养,采用HPLC测定培养液中辛伐他汀的含量。结果:各组培养液中的辛伐他汀浓度在0~96 h内的整体趋势随时间的递增逐渐减少。12 h时,不灭菌阿莫西林克拉维酸组的辛伐他汀含量明显低于灭菌阿莫西林克拉维酸组,有统计学意义(P<0.05)。结论:大鼠的肠道菌群可能参与了辛伐他汀的代谢。

关键词: font-size:medium, ">辛伐他汀;肠道菌群;抗菌药物;药物相互作用

Abstract: Objective:To investigate whether the drug interaction between simvastatin and antibiotics is related to intestinal microbiota in rats. Methods:Three commonly used oral antibiotics, cefaclor dry suspension, azithromycin dry suspension and amoxicillin-clavulanate potassium granules were selected, and SD rats were randomly divided into cefaclor group, azithromycin group, amoxicillin-clavulanate potassium group and blank group. The intestinal microbiota solution of rats was prepared by gavage according to the administration protocol. After autoclaving and non-sterilization treatments, the same amount of simvastatin was added to co-culture with intestinal microbiota solution, and the content of simvastatin in the culture solution was determined by HPLC. Results: The overall trend of simvastatin concentration in culture medium of each group decreased gradually with the increase of time from 0h to 96h. At 12h, the content of simvastatin in the non-sterilized amoxicillin-clavulanic acid group was significantly lower than that in the sterilized amoxicillin-clavulanic acid group, with statistical significance(P<0.05). Conclusion:Intestinal flora of rats may be involved in the metabolism of simvastatin.

Key words: font-size:medium, ">Simvastatin; Intestinal flora; Antibacterial drugs; Drug interactions

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