• 中国核心期刊(遴选)数据库收录期刊
  • 中文科技期刊数据库收录期刊
  • 中国期刊全文数据库收录期刊
  • 中国学术期刊综合评价数据库统计源期刊等

中国药物评价 ›› 2023, Vol. 40 ›› Issue (2): 130-136.

• 评价技术与方法 • 上一篇    下一篇

营养学随机对照试验证据质量分级系统:NutriGrade解读

 鄂芬芬1,2,3, 商雪1,2,3, 卢存存4, 李艳飞2,3, 郭康乐1,3,5, 宋桂杭6, 吴亚楠1,2,3,
     周丽营1,2,3, 李秀霞1,2,3*, 杨克虎1,2,3*   

  1. 1.兰州大学循证社会科学研究中心/兰州大学卫生技术评估中心, 兰州大学公共卫生学院, 甘肃 兰州 730000;
    2.甘肃省循证医学与临床转化重点实验室, 甘肃 兰州 730000;
    3.兰州大学循证医学中心,兰州大学基础医学院, 甘肃 兰州 730000;
    4.中国中医科学院中医临床基础医学研究所, 北京 100700;
    5.甘肃省人民医院, 甘肃 兰州 730000;
    6.甘肃省医疗保障局, 甘肃 兰州 730000
  • 收稿日期:2022-11-28 出版日期:2023-04-28 发布日期:2023-04-28
  • 基金资助:
    国家自然科学基金面上项目(编号:72074103);中央高校基本科研业务费专项资金(编号:lzujbky-2021-ct06,lzujbky-2021-kb22);甘肃省软科学专项(编号:20CX9ZA109);首都医科大学国家医疗保障研究院开放性课题(编号:YB2021B07)

Interpretation of NutriGrade: A Grading System to Assess the Quality of Evidence for Randomized Controlled Trial on Nutrition

  1. 1.Evidence Based Social Science Research Center/Health Technology Assessment Center, School of Public Health,
         Lanzhou University, Gansu Lanzhou 730000, China;
    2.Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Gansu Lanzhou 730000, China;
    3.Evidence Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Gansu Lanzhou 730000, China;
    4.Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China;
    5.Gansu Provincial Hospital, Gansu Lanzhou 730000, China;
    6.Gansu Healthcare Security Administration, Gansu Lanzhou 730000, China
  • Received:2022-11-28 Online:2023-04-28 Published:2023-04-28

摘要: NutriGrade证据质量分级系统针对营养学研究证据所基于的随机对照试验(randomized controlled trial, RCT)和队列研究分别建立了不同的证据质量分级方法。应用于随机对照试验的NutriGrade证据质量分级部分包括7个评价条目:①偏倚风险、研究质量和研究局限性(3分);②精确性(1分);③异质性(1分);④直接性(1分);⑤发表偏倚(1分);⑥资助偏倚(1分);⑦研究设计(2分)。依据评分标准分别对评价条目计分,最终将各条目的评分结果汇总转化为:高质量证据(8-10分)、中等质量证据(<8分)、低质量证据(<6分)和极低质量证据(<4分)四个证据质量等级。本文系统解读该部分NutriGrade的评价条目及评分标准,应用实例加以分析,以期为国内研究者理解和应用此工具提供参考。

关键词: font-size:medium, ">Meta分析;随机对照试验;证据分级;NutriGrade;解读

Abstract: The NutriGrade evidence quality grading system has established different quality of evidence grading methods for randomized controlled trials(RCTs) and cohort studies on which nutrition research evidence is based.The quality of evidence section of the NutriGrade for RCTs consists of seven assessment items:①risk of bias, study quality and study limitations(3 points);②precision(1 point);③heterogeneity(1 point);④directness of evidence(1 point);⑤publication bias(1 point);⑥funding bias(1 point);⑦study design(2 points). Each item is scored according to the scoring standard, and the scoring results of each item are finally summarized and transformed into four quality levels of evidence: high-quality evidence(8-10 points), moderate-quality evidence(<8 points), low-quality evidence(<6 points) and very low-quality evidence(<4 points).This paper systematically interprets the evaluation items and scoring criteria of this part of NutriGrade, and analyzes the application examples, in order to provide reference for domestic researchers to understand and apply this tool.

Key words: font-size:medium, ">Meta-analysis;Randomized controlled trial;Evidence classification;NutriGrade;Interpretation

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