关键词: font-size:medium, ">血栓通；依达拉奉右坎醇；脑梗死；神经功能

Abstract: Objective： To investigate the efficacy of Xueshuantong combined with Edaravone dexcanol in the treatment of acute progressive cerebral infarction (APCI) and the improvement of nerve function， inflammatory and oxidative stress. Methods： One hundred and twenty patients with APCI admitted to our hospital from January 2021 to June 2022 were selected and divided into 60 cases each according to random number table method. The reference group was given edaravone dexcanol， and the combination group was given Xueshuantong on this basis. The therapeutic effect， nerve function impairment (NIHSS score)， nerve injury factors (ICAM-1)， glial fibrillary acidic protein (GFAP)， β-actin (β-Actin)， brief Mental state Examination Scale (MMSE)， inflammatory and oxidative stress (interleukin-1β (IL-1β) were compared between 2 groups， matrix metalloproteinase-9 (MMP-9)， superoxide dismutase (SOD)， myeloperoxidase (MPO)]， daily living ability (BI index) and adverse reactions. Results： The total effective rate of the combined group was 88.33% higher than that of the reference group (P<0.05). After 2 weeks of treatment， the improvement of NIHSS， MMSE and BI scores in combination group was greater than that in reference group (P<0.05). ICAM-1， GFAP and β-actin in combination group were lower than those in reference group (P<0.05). The levels of IL-1β， MMP-9 and MPO in combination group were significantly lower than those in reference group， and the level of SOD was higher than that in reference group (P<0.05). There was no significant difference in the incidence of adverse reactions between groups (P>0.05). Conclusion： Xueshuantong combined with Edaravone dexcanol can alleviate nerve injury， inhibit inflammatory and oxidative stress， promote the improvement of nerve function and cognitive function， and improve the ability of daily living in patients with APCI， and has a good effect.

Key words: font-size:medium, "> , Xueshuantong； Edaravone dexcanol； Cerebral infarction； Neural function