关键词: font-size:medium, ">不溶性微粒；输液；可立袋；吹灌封(BFS)工艺；软袋；药物配伍

Abstract: Objective：To compare effects of five factors，namely，compatible environment， drugs， infusion packagings， syringe and dosage times， on the sub-visible particles in compatible infusions. Methods： Measured the sub-visible particles in sodium chloride infusions with three common plastic packagings (including inner sealed polypropylene bag， collapsible PP bottle and multi-layer co-extrusion bag) and two commonly used drugs after the compatibility through different compatibility modes， analysis of variance (ANOVA) was used to compare the effect of five factors on the sub-visible particles. Results： The results showed that syringe and drugs were the main factors affecting the number of sub-visible particles in the infusions after drug compatibility， followed by the compatible environment and dosage times. Type of infusion packagings had little effect on the number of sub-visible particles in the infusions after drug compatibility. Conclusion： When dispensing infusion solutions in clinic， it is more important to consider the influence of medical instruments and drugs on sub-visible particles than infusion packaging.
 

Key words: font-size:medium, ">Sub-visible particles； Infusion； Collapsible PP bottle； Blow-fill-seal(BFS)； Soft bag； Drug compatibility