结直肠癌患者术后化疗骨髓抑制预测价值研究及影响因素分析#br#

中国药物评价 ›› 2023, Vol. 40 ›› Issue (6): 521-524.

结直肠癌患者术后化疗骨髓抑制预测价值研究及影响因素分析#br#

徐磊1，刘全义2，刘建婷3，刘喆1，杨亮蕊2*

1.大理大学药学院，云南大理 671000； 2.大理大学第一附属医院药剂科，云南大理 671000； 3.大理大学第一附属医院肿瘤科，云南大理 671000

收稿日期:2023-09-06 修回日期:2023-09-28 出版日期:2023-12-28 发布日期:2023-12-28
基金资助:
云南省教育厅科学研究基金项目（课题名称：临床药学专硕与临床药师规培一体化培养模式的初探；项目编号：2023J0962）

Predictive Value of Postoperative Chemotherapy Myelosuppression in Patients with Colorectal Cancer and Analysis of Influencing Factors#br#

1.School of Pharmacy， Dali University， Yunnan Dali 671000， China；
2.Department of Pharmacy，The First Affiliated Hospital of Dali University， Yunnan Dali 671000， China；
3.Department of Oncology， The First Affiliated Hospital of Dali University，Yunnan Dali 671000，China

Received:2023-09-06 Revised:2023-09-28 Online:2023-12-28 Published:2023-12-28

摘要/Abstract

摘要： 目的：探讨预后营养指数(OPNI)联合营养风险筛查NRS2002表与腹腔镜下结直肠癌根治术后及化疗并发症的相关性，为改善化疗患者营养状况提供依据。方法：收集2022年3月至2023年3月大理市某医院确诊为结直肠恶性肿瘤并完成腹腔镜下恶性肿瘤根治术且规律4次化疗患者的病历资料。结果：根据纳入排除标准共入组117例患者病历资料，绘制以营养风险筛查NRS2002评分为状态变量，预后营养评分为检验变量的ROC曲线，手术前及手术后约登指数最大值为0.526时，截断值OPNI得分为42.50，特异度为0.891，敏感度为0.635。连续4次化疗过程约登指数最大值为0.355时，截断值OPNI得分为44.90，特异度为0.682，敏感度为0.673。使用OPNI值分析化疗间期患者营养状况，患者发生骨髓抑制程度与患者营养状况相关。对实验室资料进行单因素分析，将有统计学意义的变量纳入Logistic回归，结果显示：白蛋白是影响营养风险的保护因素。结论：营养评估可预测化疗引起的骨髓抑制，提高血生化中的白蛋白值，有助于患者减少化疗期间骨髓抑制的发生。
[关键词]

关键词: 结直肠癌, 预后营养指数, 营养风险, 骨髓抑制

Abstract: Objective：To investigate the correlation between prognostic nutritional index (OPNI) combined with nutritional risk screening 2002 (NRS2002) and postoperative and chemotherapy complications after laparoscopic radical resection for colorectal cancer， and to provide a basis for improving the nutritional status of patients undergoing chemotherapy. Methods：From March 2022 to March 2023， the medical records of patients who were diagnosed with colorectal malignant tumors and completed laparoscopic radical resection of malignant tumors and received 4 regular chemotherapy in a hospital in Dali City were collected.Results：A total of 117 patients were enrolled according to the inclusion and exclusion criteria. The ROC curve was drawn with nutritional risk screening 2002 score as the state variable and prognostic nutritional score as the test variable. When the maximum Youden index before and after surgery was 0.526， the cutoff value of OPNI score was 42.50. When the maximum value of Youden index was 0.355， the cutoff value of OPNI score was 44.90. OPNI value was used to analyze the nutritional status of patients during chemotherapy， and the degree of bone marrow suppression was related to the nutritional status of patients. Univariate analysis of laboratory data was carried out， and statistically significant variables were included in Logistic regression. The results showed that albumin was a protective factor for nutritional risk. Conclusion：Nutritional assessment can predict chemotherapyinduced bone marrow suppression， improve the albumin value of blood biochemistry， and help patients reduce the occurrence of bone marrow suppression during chemotherapy.

Key words: Colorectal cancer, Onodera prognostic nutrition index, Nutritional risk, Myelosuppression

中图分类号:

R735.35

徐磊, 刘全义, 刘建婷, 刘喆, 杨亮蕊. 结直肠癌患者术后化疗骨髓抑制预测价值研究及影响因素分析#br#[J]. 中国药物评价, 2023, 40(6): 521-524.

XU Lei, LIU Quan-yi, LI Jian-ting, LIU Zhe, YANG Liang-rui. Predictive Value of Postoperative Chemotherapy Myelosuppression in Patients with Colorectal Cancer and Analysis of Influencing Factors#br#[J]. CHINESE JOURNAL OF DRUG EVALUATION, 2023, 40(6): 521-524.

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