关键词: font-size:medium, ">血必净注射液；比阿培南；脓毒症休克；血流动力学；微循环；临床疗效

Abstract: Objective：To explore the effect of Xuebijing injection combined with biapenem in the treatment of septic shock patients. Methods： The clinical data of 83 patients with sepsis shock admitted to our hospital from June 2022 to May 2024 were selected for analysis. According to different treatment methods， the patients were divided into a conventional group(41 cases) and an observation group(42 cases). All patients were given conventional supportive therapy， while the conventional group was treated with biapenem， and the observation group was treated with Xuebijing injection+biapenem. The clinical efficacy， Sequential Organ Failure Assessment(SOFA) score， blood routine examination [neutrophil(N)， C-reactive protein(CRP)， white blood cell count(WBC)， erythrocyte sedimentation rate(ESR)]， hemodynamics [mean arterial pressure(MAP)， heart rate(HR)， central venous pressure(CVP)]， microcirculation status [central venous oxygen saturation(SCVO2)， central venous-arterial partial pressure of carbon dioxide difference(Pcv-aCO2)， oxygenation index， blood lactate] and prognostic indicators were compared between the two groups. Results： The total effective rate of the observation group was 90.48%， which was higher than that of the conventional group(73.17%)(P<0.05). After 3 d of treatment， the SOFA score in the observation group was decreased compared with the conventional group(P<0.05). After 3 d of treatment， the levels of N， CRP， WBC， and ESR in the observation group were decreased compared to the control group(P<0.05). After 3 d of treatment， the HR in the observation group was decreased compared with the conventional group， while MAP and CVP were increased compared with the conventional group(P<0.05). After 3 d of treatment， the Pcv-aCO2 and blood lactate levels in the observation group were decreased compared with the conventional group， while the SCVO2 and oxygenation index were increased compared with the conventional group(P<0.05). There was no significant difference in ICU admission time and 28 day survival rate between the observation group and the control group(P>0.05). Conclusion： The combination of Xuebijing injection and biapenem has significant therapeutic effects on sepsis shock， improving the patient′s hemodynamic status and microcirculatory perfusion， effectively inhibiting inflammatory reactions， and improving the patient′s health status.

Key words: font-size:medium, ">Xuebijing injection； Biapein； Septic shock； Hemodynamics； Microcirculation； Clinical efficacy