关键词: font-size:medium, ">瑞马唑仑；舒芬太尼；无痛胃镜；呛咳；镇静

Abstract: Objective： To investigate the application effect of remimazolam combined with sufentanil in painless gastroscopy， with a focus on analyzing its role in reducing coughing and improving sedation efficacy. Methods： A retrospective analysis was performed on the data of patients who underwent painless gastroscopy in our hospital from January 2022 to December 2023. A total of 120 patients were included after screening. Using the principle of random grouping， patients sedated with remimazolam combined with sufentanil were set as the observation group (60 cases)， and those sedated with propofol combined with sufentanil were set as the control group (60 cases). Coughing during the examination， sedation efficacy， vital signs， and safety indicators such as respiratory depression were compared between the two groups. Results： There were no statistically significant differences in baseline data (age， gender， BMI， ASA grade) between the two groups (P>0.05)， indicating comparability. The anesthesia onset time and recovery time in the observation group were shorter than those in the control group (P<0.05). During scope insertion and withdrawal， the fluctuations in mean arterial pressure (MAP) and heart rate (HR) in the observation group were smaller and maintained stable levels (P<0.05). The incidence of coughing in the observation group was significantly lower than that in the control group (P<0.05). Severe respiratory depression (SpO2<90%) did not occur in either group. Conclusion： Remimazolam combined with sufentanil in painless gastroscopy can effectively reduce coughing， improve sedation quality， provide better hemodynamic stability， and has good safety.

Key words: font-size:medium, ">Remimazolam； Sufentanil； Painless gastroscopy； Coughing；Sedation