百蕊颗粒联合孟鲁司特钠治疗儿童咳嗽变异性哮的临床效果分析

摘要/Abstract

摘要： 目的：分析百蕊颗粒联合孟鲁司特钠治疗儿童咳嗽变异性哮喘（CVA）的效果。方法：选取2023年9月至2024年9月郑州市妇幼保健院91例CVA患儿，根据治疗方案不同分为对照组、观察组。其中予以孟鲁司特钠治疗的46例为对照组，予以百蕊颗粒联合孟鲁司特钠治疗的45例为观察组。比较2组临床疗效、不良反应发生率和治疗4 w后临床症状改善情况和治疗前、治疗4 w后肺功能、血清炎症因子水平。结果：观察组临床总有效率（88.89 %）高于对照组（71.74 %）（P＜0.05）；观察组治疗4 w后哮鸣音、体温、咳嗽、咽痛、哮喘改善情况优于对照组（P＜0.05）；观察组治疗4 w后第1 s用力呼气容积（FEV1）、呼气流量峰值（PEF）、用力肺活量（FVC）、FEV1/FVC水平高于对照组（P＜0.05）；观察组治疗4 w后白介素（IL）-6、肿瘤坏死因子（TNF）-α、IL-4、IL-5水平降低幅度大于对照组（P＜0.05）；不良反应发生率组间比较，差异无统计学意义（P＞0.05）。结论：百蕊颗粒联合孟鲁司特钠治疗CVA患儿疗效显著，可抑制体内炎症反应、改善临床症状及肺功能，并具有一定安全性。

关键词: font-size:medium, ">百蕊颗粒；孟鲁司特钠；咳嗽变异性哮喘；临床效果

Abstract: Objective： To analyze the effect of Baier Granules combined with Montelukast sodium in the treatment of children with cough variant asthma(CVA). Methods： A total of 91 children with CVA in the Zhengzhou Maternal and Child Health Hospital from September 2023 to September 2024 were selected. Patients were divided into control group and observation group according to different treatment plans. Among them， 46 cases treated with Montelukast sodium were in the control group， and 45 cases treated with Bairui Granules combined with Montelukast sodium were in the observation group. The clinical efficacy， incidence of adverse reactions， and clinical symptom improvement after 4 weeks of treatment were compared between the two groups， as well as the lung function and serum inflammatory factor levels before and after 4 weeks of treatment. Results： The total clinical effective rate of the observation group(88.89%) was higher than that of the control group(71.74%)(P<0.05). After 4 weeks of treatment， the observation group showed better improvement in wheezing， body temperature， cough， sore throat， and asthma than the control group(P<0.05). After 4 weeks of treatment， the forced expiratory volume in 1 second(FEV1)， peak expiratory flow(PEF)， forced vital capacity(FVC)， and FEV1/FVC levels in the observation group were higher than those in the control group(P<0.05). After 4 weeks of treatment， the levels of interleukin(IL)-6， tumor necrosis factor(TNF)-α， interleukin(IL)-4， and interleukin(IL)-5 in the observation group were decreased more significantly than those in the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the groups(P>0.05). Conclusion： The combination of Bairui Granules and Montelukast sodium has significant therapeutic effects in treating children with CVA， which can inhibit inflammatory reactions in the body， improve clinical symptoms and lung function， and has certain safety.

Key words: font-size:medium, ">Bairui Granules； Montelukast sodium； Cough variant asthma； Clinical Effect

中图分类号:

赵向德, 张瑞, 王莹莹. 百蕊颗粒联合孟鲁司特钠治疗儿童咳嗽变异性哮的临床效果分析[J]. 中国药物评价, 2025, 42(2): 121-125.

ZHAO Xiangde1, ZHANG Rui2, WANG Yingying1. Effect of Combining Bairui Granules with Montelukast Sodium in Treating Children with Cough Variant Asthma[J]. CHINESE JOURNAL OF DRUG EVALUATION, 2025, 42(2): 121-125.

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