Abstract: Objective：To investigate the dissolution of amoxicillin capsules which came from four pharmaceutical companies in four kind of dissolution media， and to evaluate the comparability of dissolution curves. Methods：According to ChP 2010， water， pH 1.2 hydrochloric acid solution，pH 4.0 acetate buffer solution and pH 6.8 phosphate buffer solution were respectively used to determine the accumulative dissolution of the samples. The model independent method -f2 similarity factor method and model dependent method -weibull’s distribution model were selected to evaluate the comparability of dissolution curves. Results： A， B， and C came from domestic pharmaceutical companies， their value of T50 and Td were very close and their dissolution curves were similar； D came from pharmaceutical company of ICH members, its value of T50，Td double than that of A， B， and C， in addition， the dissolution curve was significantly different from that of A， B， and C，the similarity factors were all less than 50. Dissolution：f2 similarity factor and weibull’s distribution model method complement each other. both of them were suitable to evaluate the dissolution curve similarity of solid preparation.