• 中国核心期刊(遴选)数据库收录期刊
  • 中文科技期刊数据库收录期刊
  • 中国期刊全文数据库收录期刊
  • 中国学术期刊综合评价数据库统计源期刊等

• 药品评价-临床研究 • 上一篇    下一篇

吗替麦考酚酯联合泼尼松对难治性肾病综合征患者炎症反应及肾功能的影响

王新伟   

  1. 汝南县人民医院
  • 收稿日期:2017-10-27 修回日期:2017-11-13 出版日期:2017-12-25 发布日期:2017-12-25

Effect of Mycophenolate Mofetil Combined with Prednison on Inflammatory Reaction and Renal Function in Patients with Refractory Nephrotic Syndrome

wxw   

  1. Ruan county people''s hospital
  • Received:2017-10-27 Revised:2017-11-13 Online:2017-12-25 Published:2017-12-25

摘要: 目的: 探究吗替麦考酚酯联合泼尼松对难治性肾病综合征(RNS)患者炎症反应及肾功能的影响。结果: 选择2016年2~12月我院收治的116例RNS患者,随机将患者分为两组,各58例。对照组患者给予泼尼松+环磷酰胺注射液治疗,观察组予以吗替麦考酚酯+泼尼松治疗,比较两组肾功能、炎症因子水平及用药安全性。结果: 治疗后观察组患者临床疗效高于对照组,24 h尿蛋白定量、Scr、BUN、IL-6、TNF-α、IL-8水平及不良反应发生率等指标均明显低于对照组(P<0.05)。结论: 吗替麦考酚酯联合泼尼松能提高RNS患者的临床治疗效果,改善患者肾功能,降低炎症因子水平和不良反应发生率。

Abstract: Objective: To investigate the effect of mycophenolate mofetil (MMF) combined with prednison on inflammatory reaction and renal function in patients with refractory nephrotic syndrome (RNS). Methods: 116 cases of RNS patients in our hospital from February to December 2016 were selected and divided into two groups according to random number table, 58 cases in each group. Control group was given prednison and cyclophosphamide injection, while observation group was treated with MMF combined with prednison. The renal function, levels of inflammatory factors and drug safety were compared between the two groups. Results: After treatment, the clinical efficacy of observation group was higher than that of control group, while the levels of 24h urine protein quantity, Scr, BUN, IL-6, TNF-α, IL-8, and the incidence of adverse reactions was significantly lower than that of the control group (P<0.05). Conclusion: MMF combined with prednison in treatment of RNS can increase clinical effects, improve renal function, decrease the levels of inflammatory factors and the incidence of adverser reactions.