关键词: 舒脑欣滴丸, 脑缺血再灌注, 记忆障碍模型, 机制研究

Abstract: Objective: To observe the protective effect of shunaoxin dropping pill on the model of memory impairment induced by repeated cerebral ischemia-reperfusion in mice, and to explore its mechanism. Methods: The mouse model of memory dysfunction was made by repeated ischemia-reperfusion, and the learning and memory disorders were measured by the step-down method. The changes of oxidative stress factors were observed by the determination of SOD and MDA content in the whole brain. The brain morphology and the density of hippocampal neurons were observed by HE staining. Results: In the model mice of memory impairment caused by repeated cerebral ischemia, shunaoxin dropping pill could significantly improve the learning and memory impairment. The number of errors in the memory stage was significantly reduced, and the incubation period was significantly increased. The indexes of oxidative stress were significantly improved, and the apoptosis of hippocampal CA1 neurons was significantly reduced. Conclusion: Shunaoxin dropping pill has a good therapeutic effect on memory impairment model mice induced by cerebral ischemia-reperfusion, and its mechanism may be related to the inhibition of oxidative stress and reduction of hippocampal neuron damage.

Key words: Shunaoxin dropping pill, cerebral ischemia-reperfusion, memory disorder model, mechanism study