Abstract: Objective：To develop a method for the determination of residues of lead (Pb)， cadmium (Cd)， copper (Cu)， mercury (Hg) and arsenic (As) in the Qianliexin capsules. Methods：Samples were digested by microwave and determined by inductively coupled plasma mass spectrometry (ICP-MS). The RF power was 1.75 kW and the carrier gas flow rate was 1.05 L·min-1. Matrix effect and interference was corrected by on-line addition of internal standard elements Ge， in and Bi. Results：The linearities for the elements were good with the correlation coefficients (r) being all above 0.996 6. The RSDs of the injection precision test were in the range of 0.93% -1.68% and the RSDs of the repeatability test were in the range of 1.45% -3.03%. The recoveries of the 5 elements were in the range of 93.60% -95.90% with the RSDs being all bellow 1.69%. The digested solution was stable in 24 h. Conclusion：The method was simple， sensitive and accurate， and it can be used for the content determination of Pb， Cd， Cu， Hg， As in Qianliexin capsules， providing helpful information for the risk monitoring.