关键词: font-size:medium, ">多器官功能障碍综合征（MODS）；乌司他丁；连续性肾脏替代疗法（CRRT）；氧化应激指标

Abstract: Objective： To investigate the effects of ulinastatin combined with continuous renal replacement therapy (CRRT) for the treatment of total superoxide dismutase (T-SOD)， malondialdehyde (MDA) and total resistance oxidation capacity (T-AOC) levels in patients with multiple organ dysfunction syndrome (MODS). Methods： 42 MODS patients who received CRRT treatment in our hospital from January 2019 to December 2019 were included in the control group. 43 MODS patients who received Ulinastatin combined with CRRT treatment in the same period were collected， and included in the observation group. Both groups were treated continuously for 1 week. The levels of T-SOD， MDA and T-AOC before and after treatment were observed， and the two groups were followed up for 1 month， recorded the mortality of the two groups. Results： After treatment， the levels of T-SOD and MDA in the two groups were higher than that before treatment， and the levels of T-AOC were lower than that before treatment， and the levels of T-SOD and MDA in the observation group were higher than the control group， and the levels of T-AOC were lower than the control group. The mortality rate of the observation group (13.95%) was lower than the control group (33.33%)， the difference was statistically significant (P<0.05). Conclusion： Ulinastatin combined with CRRT in the treatment of MODS patients can effectively improve the levels of T-SOD， MDA， T-AOC and reduce the mortality.

Key words: font-size:medium, ">Multiple organ dysfunction syndrome (MODS)； Ulinastatin； Continuous renal replacement therapy (CRRT)； Oxidative stress indicators