巨噬细胞膜仿生化纳米递药系统用于炎症性疾病治疗的研究进展

摘要/Abstract

摘要： 巨噬细胞是体内一种重要的免疫细胞，与多种炎症相关疾病的发生和发展过程都息息相关。提取巨噬细胞的细胞膜并将其整合至纳米递药系统表面，制备成巨噬细胞膜仿生化纳米递药系统，既可增加纳米递药系统的生物相容性，又借助巨噬细胞膜表面膜蛋白对炎症疾病病灶部位细胞因子和趋化因子的特异性亲和作用，赋予了巨噬细胞膜仿生化纳米递药系统主动靶向病灶等生物功能，提高了药物对炎症相关疾病的治疗效率。本文旨以疾病类型作为分类归纳的线索，对巨噬细胞膜仿生化纳米递药系统在不同炎症性疾病治疗中的相关研究进行概括总结，以期为巨噬细胞膜仿生化纳米递药系统的开发和应用提供参考。

关键词: font-size:13.3333px, ">巨噬细胞膜；仿生化纳米递药系统；肿瘤；动脉粥样硬化；细菌感染性疾病

Abstract: Macrophage is an important kind of immune cells in the body， which is closely associated with the development and progression of various inflammation-related diseases. The macrophage membrane is extracted and integrated onto the surface of the nano-drug delivery system to develop the macrophage membrane-based biomimic nano-drug delivery system， which can improve the biocompatibility of the nano-drug delivery system composed of synthetic materials. Moreover， due to the high specific affinity of surface proteins on the macrophage membrane to the cytokines and chemokines at the sites of inflammatory diseases， the biomimic nano-drug delivery system can increase the lesion-targeting ability and result in enhanced therapeutic efficacy for the treatment of the inflammation-related diseases. This review summarizes recent advances in the macrophage membrane-based biomimic nano-drug delivery system for the treatment of typical inflammatory diseases， which will offer an insight into the development and application of macrophage membrane-based biomimic nano-drug delivery system.

Key words: font-size:13.3333px, ">Macrophage membrane； Biomimic nano-drug delivery system； Tumor； Atherosclerosis； Bacterial infections

中图分类号:

黄雪超, 沈诗洋, 莫然. 巨噬细胞膜仿生化纳米递药系统用于炎症性疾病治疗的研究进展[J]. 中国药物评价, 2021, 38(4): 279-283.

HUANG Xue-chao, SHEN Shi-yang, MO Ran. Advances in Macrophage Membrane-based Biomimic Nano-drug Delivery System for Inflammatory Disease Treatment[J]. CHINESE JOURNAL OF DRUG EVALUATION, 2021, 38(4): 279-283.

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