关键词: font-size:medium, ">壮药；虎刺楤木；黄毛楤木；急性毒性

Abstract: Objective： To compare the acute toxicity of different components from two sources of traditional Zhuang medicine “Yingbupu” and to provide experimental data for safety use in clinical. Methods： Prepare the water extract and alcohol extract of the two plants of Yingbupu， and compare the acute toxicity on mice in accordance with classical acute toxicity test method. Results： The acute toxicity of Yingbupu from different sources was： Aralia armata (Wall.) Seem.> Aralia decaisneana Hance， and the acute toxicity of different components was： alcohol extraction > water extraction. The LD50 values of the water extraction in Aralia armata (Wall.) Seem. is 99.0 g·kg-1 and 57.4 g·kg-1， and the 95% confidence interval is 66.2-148.0 g·kg-1， which is equivalence to clinical 254.8 times of 70 kg people′s daily dried medicinal herb dose. The LD50 values of the alcohol extraction in Aralia armata (Wall.) Seem. is 57.4 g·kg-1， and the 95% confidence interval is 49.6-66.4 g·kg-1， which is equivalence to clinical 192.1 times of 70 kg people′s daily dried medicinal herb dose. The LD50 values of water extraction and alcohol extraction in Aralia decaisneana Hance can not be speculate， so the Maximum dose are calculated were 100 g·kg-1. Diarrhea， lazy， and uncoloured hair were the main acute toxic symptoms. Conclusion： The traditional Zhuang medicine “Yingbupu” have a certain acute toxicity， and the toxicity from different plants is quite different. The acute toxicity from Aralia armata (Wall.) Seem.was stronger than that from Aralia decaisneana. Hance， Prompt in clinical use should determine the dosage according to the plant of medicinal materials. 

Key words: font-size:medium, ">Traditional Zhuang medicine； Aralia armata (Wall.) Seem.；Aralia decaisneana Hance；Acute toxicity