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中国药物评价 ›› 2020, Vol. 37 ›› Issue (5): 366-369.

• 评价技术与方法 • 上一篇    下一篇

微波消解原子吸收/原子荧光分光光度法测定卷柏总黄酮中重金属的残留

李彦超1, 周宁2, 郑晓珂2   

  1. 1.河南省食品药品检验所,国家药品监督管理局中药材及饮片质量控制重点实验室, 
         河南 郑州 450009;
    2.河南中医药大学, 河南 郑州 450046
  • 收稿日期:2020-05-28 修回日期:2020-08-27 出版日期:2020-10-28 发布日期:2020-10-28
  • 基金资助:
    国家重大新药创制-科技重大专项(2013ZX09102-022)

Residue of Heavy Metal Ingredients in Total Flavonoids of Selaginella by AAS and AFS

  1. 1. Atate drug Administration-key Laboratory of Quality Control of Chinese Medicinal Materials and Decoction Pieces,
         Henan Institute for Food and Drug Control, Henan Zhengzhou 450009, China;
    2. Henan University of Chinese Medicine, Henan Zhengzhou 450046, China
  • Received:2020-05-28 Revised:2020-08-27 Online:2020-10-28 Published:2020-10-28

摘要: 目的: 建立卷柏总黄酮重金属残留量测定方法。方法:采用微波消解法处理样品,用原子吸收分光光度法和原子荧光分光光度法测定卷柏总黄酮中铅(Pb)、镉(Cd)、铜(Cu)、砷(As)和汞(Hg)重金属元素的含量。结果:Pb、Cd、Cu、As和Hg 5种重金属元素检测及方法学考察,标准曲线的线性相关系数均>0.998,平均加样回收率分别为98.28%、97.31%、97.83%、97.49%和97.65%。4批样品的重金属残留量均在限度范围内。结论:该方法适用于卷柏总黄酮的重金属限量控制。

关键词: font-size:medium, ">卷柏总黄酮;原子吸收分光光度法;原子荧光分光光度法;重金属

Abstract: Objective: To estabish a method of determine the residue of heavy metals ingredients in total flavonoids of Selaginella. Methods: Microwave digestion was adopted to treat samples and the content of Pb,Cd,As,Hg and Cu in total flavonoids of Selaginella was measured by using atomic absorption spectrometry and atomic fluorescence spectrometry. Results:The results were reasonable and effective through the detection and have a good methodological study of Pb, Cd, As, Hg and Cu. The linear correlation coefficients were greater than 0.998. The average recoveries were 98.28%, 97.31%, 97.83%, 97.49% and 97.65%。The heavy metal residues of 4 batches of samples are within limits. Conclusion: The method is simple, rapid, accurate and reproducible, which provides a reference for the quality control of total flavonoids of Selaginella .
    

Key words: font-size:medium, ">Total flavonoids of Selaginella; Atomic absorption spectrometry; Atomic fluorescence spectrometry; Heavy metal

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