关键词: font-size:medium, ">磷酸苯丙哌林；多晶型；表征；平衡溶解度

Abstract: Objective：The polymorphs research of benproperine phosphate provides technical support for improvement of API quality and production process. Methods：Three different crystal forms of benproperine phosphate which were diffrent from API crystal form were obtained by recrystallization in different solvents. Four crystal forms of benproperine phosphate were characterized by powder Xray diffractometer， scanning electron microscope， differential scanning calorimetry and thermogravimetric analysis， melting point determination and infrared absorption spectrum， and their equilibrium solubility in different pH buffers was determined. Results：Four different crystal forms of benproperine phosphate had different Xray characteristic peaks， and the appearance and morphology of electron microscope are also obviously different. The equilibrium solubility of three new crystal forms in three kinds of buffers was significantly improved. Conclusion：By adjusting the crystallization solvent of benproperine phosphate， the crystal forms with better equilibrium solubility can be obtained.

Key words: Benproperine phosphate, Polymorphs, Characterization, Equilibrium solubility