关键词: font-size:medium, ">复方大青叶合剂；指纹图谱；质量控制

Abstract: Objective： Establish a fingerprint of Compound Daqingye Mixture to provide a basis for its quality control. Methods： HPLC method was used for determination， with Shim-pack GIST C18 as the chromatographic column(250 mm×4.6 mm， 5 μm). The mobile phase is methanol-0.02% phosphoric acid， gradient elution， flow rate is 1.0 mL·min-1， and detection wavelengths are 260 nm and 326 nm. Results： A total of 20 common peaks were identified， and 8 components were identified through comparison with reference materials， including adenosine， gallic acid， chlorogenic acid， purple flower front saponin， aloe emodin， rhein， emodin， and chrysophanol.There are differences in the similarity between different manufacturers and different batches of formulations from the same manufacturer. Conclusion： The HPLC fingerprint established in this study has good stability and repeatability， providing a reference for the quality control of Compound Daqingye Mixture.

Key words: font-size:medium, "> , Compound Daqingye Mixture； Fingerprint； Quality control