关键词: font-size:medium, ">慢性心力衰竭；心脉隆注射液；瑞舒伐他汀；心功能；血管内皮功能

Abstract: Objective： To investigate the effect of Xinmailong injection combined with Rosuvastatin on cardiac function and vascular endothelial function in patients with chronic heart failure(CHF). Methods： Data from 102 CHF patients admitted to our hospital between August 2022 and September 2024 were collected for retrospective study. According to the experimental matching design principle(1∶1)， the patients were divided into two groups based on different treatment methods. Among them， 51 cases in the control group were treated with conventional therapy+Rosuvastatin， and 51 cases in the study group were treated with Xinmailong injection in addition to the control group. Both groups were treated for 14 days. The clinical efficacy and adverse reactions of the two groups were compared， as well as the TCM syndrome scores， Minnesota Living with Heart Failure Questionnaire(MLHFQ)， cardiac function and exercise tolerance [left ventricular end-diastolic diameter(LVEDD)， left ventricular ejection fraction(LVEF)， ratio of early diastolic flow velocity(VE) to atrial systolic flow velocity(VA) in mitral valve flow(VE/VA)， 6-minute walk distance(6MWD)]， vascular endothelial function [nitric oxide(NO)， endothelin-1(ET-1)， vascular endothelial growth factor(VEGF)] before and after treatment for 14 days. Results： The therapeutic efficacy of the study group was superior to that of the control group(P<0.05). After 14 days of treatment， the study group had lower scores in palpitations， shortness of breath， fatigue， chills， cold limbs， blue lips and nails， and MLHFQ scores than the control group(P<0.05). After 14 days of treatment， LVEF， VE/VA， 6MWD， and NO in both groups were increased， while LVEDD， ET-1， and VEGF were decreased， the improvement in the study group was more significant(P<0.05). There was no significant difference in adverse reactions between the groups(P>0.05). Conclusion： Xinmailong injection combined with Rosuvastatin can improve the efficacy of CHF patients， improve clinical symptoms and quality of life， enhance cardiac function and exercise tolerance， and enhance vascular endothelial function.

Key words: font-size:medium, ">Chronic heart failure； Xinmailong injection； Rosuvastatin； Heart function； Vascular endothelial function